ANALYTICAL JUSTIFICATION OF THE MAXIMUM PERMISSIBLE CONCENTRATION OF DIDECYLDIMETHYLAMMONIUM CHLORIDE IN THE AIR OF PRODUCTION PREMISES

Abstract

Abstract. Didecyldimethylammonium chloride is a fourth-generation quaternary ammonium compound, which belongs to the group of cationic surfactants. They disrupt intermolecular interactions and dissociation of lipid bilayers. This chemical has several biocidal applications: a microbiostatic disinfectant for mold prevention, wood protection, and the destruction of algae, phytopathogenic molds, and bacteria; an active ingredient in a large number of disinfectants registered with the US Environmental Protection Agency (USEPA) and labeled for the inactivation of avian influenza A viruses on hard surfaces. Didecyldimethylammonium chloride is used in gynecology, surgery, ophthalmology, pediatrics, as well as for sterilization of surgical instruments, endoscopes and surface disinfection. Under production and usage conditions, didecyldimethylammonium chloride may get into the body of workers through inhalation or skin contact, which requires justification of the maximum permissible concentration (MPC) in the air of production premises. Purpose of the work. Analysis of literature data on the toxicity and the nature of the biological effect of didecyldimethylammonium chloride on the human body and justification of MPC in the air of industrial premises. Analysis of literature data has found that didecyldimethylammonium chloride, in terms of acute toxicity parameters, is classified as a moderately hazardous substance (hazard class 3) when administered as a single intra-gastric dose, as a highly hazardous substance (hazard class 1) when administered as a single inhalation dose and when applied to the skin for a single time, it is classified as a low-hazard substance (hazard class 4). It has resorptive-toxic effects when applying to the skin, weak cumulative properties and shows irritating effects when it contacts the skin and mucous membranes, not causing sensitization of the body. Mutagenic, carcinogenic, embryotoxic, teratogenic effects and toxic effects on reproductive function are not limiting criteria for the hazardousness of didecyldimethylammonium chloride. The MPC of didecyldimethylammonium chloride in the air of industrial premises is 0.1 mg/m3, aerosol, hazard class 1, mark + – requires special protection of the skin and eyes.