SCIENTIFIC JUSTIFICATION OF THE MEDICAL AND SANITARY STANDARD FOR THE PERMISSIBLE CONTENT OF SODIUM PERMANGANATE IN THE AIR OF THE WORKING AREA

Abstract

Abstract. Sodium permanganate is an inorganic compound, a salt of sodium and permanganic acid. It is used in industrial processes, water purification and other types of economic activity as a reagent (strong oxidant) and disinfectant. When using sodium permanganate or its aqueous solutions, this compound can enter the air of the working area in the form of dispersion aerosols and negatively affect the health of employees, which necessitates the development of a medical and sanitary standard for the permissible content in the air of the working area. The aim of the work was to experimentally determine the toxicity parameters of sodium permanganate to defining the nature of the biological effect on the organism of warm-blooded animals and to scientifically substantiate the medical and sanitary standard for the permissible content in the air of the working area. Sodium permanganate was studied in acute and subacute experiments. The work was carried out on laboratory animals (white male rats, white male mice, guinea pigs, and rabbits). The conducted experimental studies and analysis of literature data revealed that sodium permanganate, according to acute toxicity parameters with a single oral administration is classified as a moderately hazardous substance (hazard class 3), while with a single inhalation exposure, it is classified as an extremely hazardous substance (hazard class 1). The clinical picture of acute poisoning is dominated by symptoms of damage to the respiratory and central nervous systems. Sodium permanganate has a strong cumulative activity, exhibits a moderate irritant effect when applied to the skin and a strong irritant effect when it comes into contact with mucous membranes and belongs to substances with a selective irritant effect. With long-term exposure, sodium permanganate causes neurological disorders, may affect reproductive function and has no sensitizing or mutagenic effects. The carcinogenic effect has not been proven. The medical and sanitary standard of sodium permanganate in the air of the working area 0.1 mg/m3, 1st hazard class, aerosol, mark I – irritant effect. Conclusion. The toxicity parameters and the nature of the biological effect on laboratory animals have been determined and the medical and sanitary standard for the permissible content of sodium permanganate in the air of the working area has been justified.