CLINICAL EVALUATION OF THE EFFECTIVENESS OF THE USE OF LIASTENE AND PENTOXYLINE IN THE COMPLEX THERAPY OF PATIENTS WITH MULTIDRUG-RESISTANT TUBERCULOSIS

Abstract

Abstract. Tuberculosis (TB) remains one of the main causes of declining health and mortality in the World, and the current rate of decline in the epidemiological burden of TB is not fast enough, despite advances in treatment and prevention. The spread of the TB/HIV epidemic is an objective threat on a national scale and continues to negatively affect the working and reproductive potential of the population of many countries around the World. Since 2020, there has been a tendency to increase the incidence of chemoresistant (CR) TB in Ukraine. In recent years, the frequency of disseminated and fibro-cavernous TB has increased in the clinical structure of MR-TB. Almost all patients have destruction with bacterial secretion. A significant role in the deterioration of the epidemiological situation in Ukraine was affected by COVID-19 and the terrible war that is taking place in our time. One of the reasons for the low effectiveness of treatment of patients is the presence of chemoresistant forms of TB. The problem of improving etiotropic and pathogenetic therapy of CR-TB remains relevant. The purpose of the work – is to study the effectiveness of the use of Liasten (L) and Pentoxylin (P) in the treatment of patients with multidrug-resistant tuberculosis. Research results. 53 medical files of patients with multidrug-resistant TB were analyzed. Liastena (L) and Pentoxifylline (P) were used as pathogenetic drugs on the background of antimycobacterial therapy (AMBT). Patients were divided into three groups: the first, control 22 patients who received only AMBT; the second 15 people, in the complex treatment of whom Liasten (AMBT+L) was added, and the third group (16 people) – received L+P (AMBT L+P) on the background of AMBT. All patients in the intensive phase of AMBT (before treatment, after 2, 4, 6 and 8 months) underwent a complex clinical-x-ray, microbiological and general laboratory examination. Conclusions. There is an acceleration of the term of cessation of bacterial secretion, resorption of foci and infiltration and healing of decay cavities, compared to the control, when used L+P on the background of AMBT.