EXPERIMENTAL STUDY OF A SINGLE INHALATION EFFECT OF SODIUM PEROXOCARBONATE ON LABORATORY ANIMALS
Keywords:
sodium peroxocarbonate, inhalation effect, specific irritant effect.Abstract
Annotation. The article contains the results of studies on the effects of sodiumperoxocarbonate on the body of female rats with a single inhalation intake. According to the results of research, the threshold of acute inhalation action was established according to hematological indicators, as well as indicators of "percentage of macrophages" in bronchoalveolar lavage fluid (BALF) In case of a single inhalation impact sodium peroxocarbonate causes a disruption of the functional state of the respiratory system at a concentration below the threshold of acute inhalation action according to general toxic effect and, accordingly, refers to substances with specific irritant effect.
References
Basketter D.A. et al. (1997), "The classification of skin irritants by human patch test", Food and Chemical Toxicology 35, p. 845-852
Basketter D.A. et al. (2004), "Determination of skin irritation potential in the human 4-h patch test", Contact Dermatitis 51, p. 1-4
Chater B.V. (1978), "Sodium Percarbonate, Acute Oral Toxicity with Histology, Skin and Eye irritation", ICI Report CTL/T/1151
Discoll R. (1995), "Sodium Carbonate Peroxyhydrate: Acute Eye Irritation Test in the Rabbit", Solvay Duphar Int. Doc. No. 56352/55/95
OECD SIDS sodium carbonate. (n.d.). Retrieved October 17, 2021, from https://hpvchemicals.oecd.org/ui/handler.axdid=5A6538BE-AA30 4A72-AD1C-906D9B5413BD
https://echa.europa.eu/registration-dossier/-/registered-dossier/15960/7/1
Закон Украины № 3447-ΙV. О защите животных от жестокого обращения Відомості Верховної Ради України (ВВР). Київ, 2006. № 27. 230 с.
Походзей Ю.И., Пчелинцев И.А., Сергеюк Н.П. Натрия перкарбонат. Токсикологический весник. 1994.3. 47.
Методические указания к постановке исследований по изучению раздражающих свойств и обоснованию предельно допустимых концентраций избирательно действующих раздражающих веществ в воздухе рабочей зоны» утв. 11 августа 1980 г. № 2196-80.
