DETERMINATION OF INTERFERONINDUCING ACTIVITY OF VIRUS STRAINS TICK-BITABLE ENCEPHALITIS – POTENTIAL CANDIDATES FOR THE PRODUCTION OF IMMUNOBIOLOGICAL PREPARATIONS
DOI:
https://doi.org/10.32782/2786-9067-2023-25-6Keywords:
tick-borne encephalitis viruses, interferoninducing activity.Abstract
Abstract. The results of an experimental study on the interferoninducing activity of 10 selected strains of the tick-borne encephalitis virus in laboratory mice with the aim of identifying potential candidates for the production of immunobiological drugs are given. It was established that the investigated strains of the tick-borne encephalitis virus mainly have high interferoninducing activity, which was characterized by wave-like dynamics with two pronounced, as a rule, peaks of interferon accumulation in the blood of mice. The most optimal candidate for the production of a specific vaccine, serum and immunoglobulin should be considered strain No. 2288, which in a comparative study with other strains showed the strongest and longest interferon-inducing effect.
References
Виноград І.А. Лозинський І.М. Арбовіруси та арбовірусні інфекції у лісостеповій зоні України. Мікробіол. журнал. 1998. № 2. С. 49-60.
Lozynskiy I.. Biletska H., Semenyshyn O., FedorukV., Drul O., Ben I., Shulgan A., Morochkovski R. Active natural foci of tick-borne neuroinfections in the North-West region of Ukraine. Encephalitis / Edited by Dr. Sergey Tkachev. InTech, 2013. P. 145–160.
Yurchenko O.O., Dubyna D.O., Vynograd N.O., Rogovskyy A.S. Tick-borne encephalitis cases recorded in Ukraine over 1990–2018. Journal of Travel Medicine, 2020, Vol. 27, 4. P. 1–3.
Чижов Н.П., Ершов Ф.И., Индулен М.К. Основы экспериментальной химиотерапии вирусных инфекций. -Рига: Зинатне, 1988. 171с.
European Convention for the Protection of Vertebrane Animals used for Experimental and Other Scientific Purposes: European Communities (EC) –Strasbourg, 18.03.1986. European Treaty Series No. 123.
Смородинцев А.А., Дубов А.В. Клещевой энцефалит и его вакцинопрофилактика. -Л.: Медицина, 1986. 232 с.
Шлезингер М.Дж. Репликация тогавирусов. Вирусология. –М.: Мир, 1989. С. 343-365 с.
Верета Л.А., Воробьева М.С. Природная гетергенность и целенаправленный отбор штаммов вируса клещевого энцефалита. - М.: Медицина. 1990. 123 с.
