TOXICOLOGICAL CHARACTERISTICS OF N,N-DIETHYLMETHYLBENZAMIDE (DETA)

Authors

DOI:

https://doi.org/10.32782/2786-9067-2023-25-11

Keywords:

N,N-diethylmethylbenzamide, repellent, toxicity parameters, maximum permissible concentration, air of industrial premises.

Abstract

Abstract. On the basis of the toxicity parameters of the N,N-diethylmethylbenzamide repellent, which are given in the scientific literature, the maximum permissible concentration in the air of industrial premises at the level of 5 mg/m3 (aerosol + vapors) 3 danger class is proposed.

References

Sudakin D.L., Osimitz T. Handbook of Pesticide Toxicology (Third Edition), 2010. P. 2111-2125.

Ambrose A.M. Pharmacologic and toxicologic studies on N,N-diethyltoluamide. I. N,N-diethyl-m-toluamide. Toxicol Appl Pharmacol. 1959. №1. P. 97-115.

N,N-Diethyl-m-toluamide (DEET). [134-62-3]. Review of Toxicological Literature. National Institute of Environmental Health. https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/deet_508.pdf. (дата звернення 24.11.2021).

Тимофиевская Л.А., Заева Г.Н. Нормирование модельных репеллентов на кожных покровах — основа ускоренной оценки их препаративных форм. Современные проблемы токсикологии.1999.№4. C. 42-45.

WHO. 1987. Data sheet on pesticides No. 80: DEET. World Health Organization.

McCain W.C, Lee R., Johnson M.S. et al. Acute oral toxicity study of pyridostigmine bromide, permethrin, and DEET in the laboratory rat. J Toxicol Environ Health. 1997. №50(2). P. 113-124.

Heick H.M., Peterson R.G., Dalpe-Scott M., Qureshi I.A. Insect repellent, N,N-diethyl-m-toluamide, effect on ammonia metabolism. Pediatrics. 1988. № 82(3). P. 373-376.

Behavioral effects of acute aerosol exposure to N,N-diethyl-meta-toluamide (M-DET). January -February 1979. Toxicological Assessment Program Study No75-51-0034-80. Fort Sam, Houston, TX: U.S. Army. 1979. 28 pp.

Deb U., Ahmed F., Singh S., Mendki M.J., Vijayaraghavan R. Comparative effects of insect repellent N,N-diethylbenzamide, N,N-diethylphenylacetamide, and N,N-diethyl-3-methylbenzamide. Inhal. Toxicol. 2010. № 22(6). P. 469-478.

Tenjarla S.N., Holbrook J.H., Puranajoti P., Pegg C., Lowe K.D., Jackson T.E., Smith A. Evaluating the irritation potential of skin penetration enhancers in hairless guinea pig. J. Toxicol.-Cut. Ocular Toxicol. 1995. № 14(4). P. 299-307.

Carpenter C.P., Weil C.S., Smyth H.F. Range-finding toxicity data: List VIII. Toxicol Appl Pharmacol. 1974. № 28. P. 313-319.

Registration eligibility decision (RED): DEET. Washington, DC: US Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances. https://archive.epa.gov/pesticides/reregistration/web/pdf/0002red.pdf. (дата звернення: 27.11.2021).

Mac Rae S.M., Brown B.A., Ubels J.L. et al. Ocular toxicity of diethyltoluamide. J Toxicol Cutaneous Ocul Toxicol. 1984. №3(1). P. 17-30.

Kellner T.P., Hanes M.A., Fruin J.T. Primary eye irritation potential of the insect repellents CHF-1 and m-DEET. Technical Note No. 81-23TN. May-June 1981. San Francisco, CA: Letterman Army Institute of Research.

Topper M. J., Weeks M. H. Acute eye irritation study of N,N-diethyl-m-toluamide (m-DET). Study No. 75-51-0034-81. February-March 1981. Aberdeen Proving Ground, MD: U. S. Army Environmental Hygiene Agency. NTIS No. NTIS/AD-A098561/4. 1981. 65 pp.

M-DET. Phase 5, Subchronic -0034-80, September 1978-May 1979. Fort Sam, Houston, TX: US. Army. 1980. 25 pp.

DEET: Review of a two-generation reproduction in rats and a 90-day dose-range finding study in hamsters. Washington, DC: U.S. Environmental Protection Agency.1990. MRID No. 413441-01, 409790-01; HED Project No. 0-0837.

Schoenig G.P., Osimitz T.G., Gabriel K.L. et al. Evaluation of the chronic toxicity and oncogenicity of N,N-diethyl-m-toluamide (DEET). Toxicol Sci. 1999. №47(1). P. 99-109.

Petrucci N., Sardini S. Severe neurotoxic reaction associated with oral ingestion of low-dose diethyltoluamide-containing insect repellent in a child. Pediatr Emerg Care. 2000. №16 (5). P. 341-342.

Edwards D.L., Johnson C.E. Insect-repellent-induced toxic encephalopathy in a child. Clin Pharm. 1987. №6 (6). P. 496-498.

Tenenbein M. Severe toxic reactions and death following the ingestion of diethyltoluamide-containing insect repellents. JAMA. 1987. № 258 (11). P. 1509-1511.

Zadikoff C.M. Toxic encephalopathy associated with use of insect repellent. J Pediatr. 1979. № 95(1). P.140-142.

Wiles D., Yee J., Castillo U., Russell J., Spiller H., Casavant M. A lethal case of DEET toxicity due to intentional ingestion. J Anal Toxicol. 2014. № 38(9). P. 696-698.

Schoenig G.P., Hartnage R.E., Schardein J.L. et al. Neurotoxicity evaluation of N,N-diethyl-m-toluamide (DEET) in rats. Fundam Appl Toxicol. 1993. № 21(3). P. 355-365.

Hoy J.B., Cornell J.A., Karlix J.L. Interactions of pyridostigmine bromide, DEET and permethrin alter locomotor behavior of rats. Vet Hum Toxicol. 2000. № 42(2). P.65-71.

Verschoyle R.D, Brown A.W, Nolan C. A comparison of the acute toxicity, neuropathology, and electrophysiology of N,N-diethyl-m-toluamide and N,N-dimethyl-2,2-diphenylacetamide in rats. Fundam Appl Toxicol. 1992. №18(1). P.79-88.

Schoenig G.P, Hartnage R.E, Schardein J.L., Vorhees C.V. Neurotoxicity evaluation of N,N-diethyl-m-toluamide (DEET) in rats. Fundam Appl Toxicol. 1993. № 21(3). P. 355-365.

Inhalation toxicities of N,N-diethyl-meta-toluamide (M-DET) Study No. 75-51-0034-80, January -May 1979. Fort Sam Houston, TX: U.S. Army.

EPA memorandum 007645 from Whang Phang, Subject: Review of a two-generation reproduction on DEET, dated 13 December 1989. Washington, DC: U.S. Environmental Protection Agency. https://archive.epa.gov/pesticides/chemicalsearch/chemical/foia/web/html/080301. (дата звернення 29.11.2021).

Published

2022-12-30