MULTI DRUG-RESISTANT AND EXTENSIVELY DRAG RESISTANT ACINETOBACTER SPECIES ISOLATED IN LVIV DURING 2021-2022

Authors

DOI:

https://doi.org/10.32782/2786-9067-2023-25-17

Keywords:

Acinetobacter spp, resistance to antimicrobials, multi drug-resistancе (MDR), extensively drug-resistancе (XDR).

Abstract

Abstract. The antibiotic susceptibility profile of 45 Acinetobacter spp isolated in Lviv during 2021-2022 was studied. All of the tested isolates were multi drug-resistanc (MDR), 77,8 + 5,8 % isolates have extensively drug-resistanc (XDR). All Acinetobacter isolates were sensitive to colistin and polimixin B.

References

Basak S., Singh P., Rajurkar M. Multidrug Resistant and Extensively Drug Resistant Bacteria: A Study. J Pathog. 2016;2016:4065603. doi: 10.1155/2016/4065603.

De Oliveira D. M. P, Forde B. M., Kidd T. J., Harris P. N. A., Schembri M. A., Beatson S. A., Paterson D. L., Walker M. J. 2020. Antimicrobial resistance in ESKAPE pathogens. Clin Microbiol Rev 33:e00181-19. https://doi.org/10.1128/CMR.00181-19

EUCAST Disk Diffusion Method for Antimicrobial Susceptibility Testing Version 10.0, 2022 http://www.eucast.org

Lupo A., Haenni M., Madec J.Y. Antimicrobial Resistance in Acinetobacter spp. and Pseudomonas spp. Microbiol Spectr. 2018 Jun;6(3). DOI: 10.1128/microbiolspec.ARBA-0007-2017.

Maeusli M., Lee B., Miller S., Reyna Z., Lu P., Yan J., Ulhaq A., Skandalis N., Spellberg B., Luna B. Horizontal gene transfer of antibiotic resistance from Acinetobacter baylyi to Escherichia coli on lettuce and subsequent antibiotic aesistance transmission to the gut microbiome. mSphere. 2020 May 27;5(3):e00329-20. DOI: 10.1128/mSphere.00329-20.

Magiorakos A.P., Srinivasan A.,. Carey R. B. Et al Multidrugresistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance, Clinical Microbiology and Infection, vol. 18, no. 3, pp. 268–281, 2012. DOI: 10.1111/j.1469-0691.2011.03

Naiemi N. A., Duim B., Savelkoul P. H., Spanjaard L., de Jonge E., Bart A., Vandenbroucke-Grauls C. M., de Jong M. D. Widespread transfer of resistance genes between bacterial species in an intensive care unit: implications for hospital epidemiology. J Clin Microbiol. 2005. Sep;43(9):4862-4864. DOI: 10.1128/JCM.43.9.4862-4864.2005.

Shi J., Sun T., Cui Y., Wang C., Wang F., Zhou Y., Miao H., Shan Y., Zhang Y. Multidrug resistant and extensively drug resistant Acinetobacter baumannii hospital infection associated with high mortality: a retrospective study in the pediatric intensive care unit. BMC Infect Dis. 2020 Aug 12;20(1):597. DOI:10.1186/s12879-020-05321-y.

The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 12, 2022. http://www.eucast.org

Wong D., Nielsen T. B., Bonomo R. A., Pantapalangkoor P., Luna B., Spellberg B. Clinical and pathophysiological overview of Acinetobacter Infections: a century of challenges. Clin Microbiol Rev. 2017 Jan;30(1):409-447. doi: 10.1128/CMR.00058-16.

Zarrilli R., Visca P., Bonnin R. A., Dé E. Editorial: drug resistance, global epidemiology and virulence of Acinetobacter. Front Microbiol. 2023 Feb 21;14:1151462. DOI:10.3389/fmicb.2023.1151462. PMID: 36896428; PMCID: PMC9989

Published

2022-12-30