PSEUDOMONAS AERUGINOSA IN PATIENTS WITH MINE BLAST INJURIES

Authors

DOI:

https://doi.org/10.32782/2786-9067-2023-25-19

Keywords:

P. aeruginosa, pyocyanin, multidrug resistance, mine blast injuries.

Abstract

Abstract. During the Russian aggression, Ukraine faces many problems in various spheres of life. Due to the large flow of patients, it is extremely difficult to ensure a high-quality anti-epidemic regime in medical institutions located close to the front line. After receiving first aid, patients are transferred to hospitals in civilian areas for further inpatient treatment and prosthetics. Purulent and septic complications of gunshot wounds develop in 50-75% of cases. The results of microbiological studies of the wounds of victims of explosive or mine-blast wounds showed the prevalence of gram-negative microflora. Antibiotic-resistant P. aeruginosa infecting war-related wounds is a serious problem with regional and global implications that requires regular antibiotic susceptibility testing. The study aimed to isolate pseudomonads that complicate the course of wound healing, which delays the possibility of prosthetics for patients, and to determine the spectrum of sensitivity of the isolated strains to antibacterial drugs. The isolated pseudomonads were resistant to almost all antibiotics recommended for testing by the EUCAST guidelines. Promising studies include the search and testing of new antimicrobial agents with high activity against resistant P. aeruginosa isolates Funding: This work was supported by the Ministry of Health of Ukraine [grant number: 0123U100153].

References

Хоменко І. П. Динаміка мікробної контамінації вогнепальної рани під час комплексного хірургічного лікування / І. П. Хоменко, Є. В. Цема, В. Ю. Шаповалов, С. В. Тертишний, П. О. Шкляревич // Хірургія України. - 2018. - № 1. - С. 7-13. http://nbuv.gov.ua/UJRN/KhU_2018_1_3

Prevalence of MDR Pseudomonas aeruginosa of war-related wound and burn ward infections from some conflict areas of Western Yemen Mahfouz Nasser, Mahmoud Ogali, Arun S. Kharat Wound Medicine, 2018;20:58-61 https://doi.org/10.1016/j.wndm.2018.02.001

Laborda P, Hernando-Amado S, Martínez JL, Sanz-García F. Antibiotic Resistance in Pseudomonas. Adv Exp Med Biol. 2022;1386:117-143. doi: 10.1007/978-3-031-08491-1_5. PMID: 36258071

Laborda P, Martínez JL, Hernando-Amado S. Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa. Microbiol Spectr. 2022 Aug 31;10(4):e0024722. doi: 10.1128/spectrum.00247-22. Epub 2022 Jun 29. PMID: 35766499; PMCID: PMC9431229.

Документи Європейського комітету з визначення чутливості до антимікробних препаратів (European Committee on Antimicrobial Susceptibility Testing — EUCAST) https://www.phc.org.ua/kontrol-zakhvoryuvan/antimikrobna-rezistentnist/normativna-dokumentaciya

Scudeller L, Righi E, Chiamenti M, Bragantini D, Menchinelli G, Cattaneo P, Giske CG, Lodise T, Sanguinetti M, Piddock LJV, Franceschi F, Ellis S, Carrara E, Savoldi A, Tacconelli E. Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli. Int J Antimicrob Agents. 2021 May;57(5):106344. doi: 10.1016/j.ijantimicag.2021.106344. Epub 2021 Apr 20. PMID: 33857539.

Menon ND, Penziner S, Montaño ET, Zurich R, Pride DT, Nair BG, Kumar GB, Nizet V. Increased Innate Immune Susceptibility in Hyperpigmented Bacteriophage-Resistant Mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0023922. doi: 10.1128/aac.00239-22. Epub 2022 Jul 6. PMID: 35862755; PMCID: PMC9380547.

Кожухар Р. С. Біосинтез феназинових пігментів Pseudomonas aeruginosa за різних умов культивування. Biosynthesis of phenazine pigments by Pseudomonas aeruginosa under different culture conditions : дипломна робота магістра / Р. С. Кожухар. – Одеса, 2019. – 54 с. http://dspace.onu.edu.ua:8080/handle/123456789/30905

Kothari A, Kumar SK, Singh V, Kumar P, Kaushal K, Pandey A, Jain N, Omar BJ. Association of multidrug resistance behavior of clinical Pseudomonas aeruginosa to pigment coloration. Eur J Med Res. 2022 Jul 16;27(1):120. doi: 10.1186/s40001-022-00752-6. PMID: 35842687; PMCID: PMC9288039.

Emergency war surgery 5th Edition / senior editor, Miguel A. Cubano ; co-editors, Frank Butler [and 13 others]; contributors, Hernan O. Altamar [and 58 others]. 2018. 553р. https://medcoe.army.mil/borden-tb-ews

Published

2022-12-30