THE DYNAMICS OF IMMUNOLOGICAL CHANGES IN THE ORAL FLUID OF CHILDREN WITH OVERWEIGHT DURING THE TREATMENT OF CHRONIC CATARRHAL GINGIVITIS
DOI:
https://doi.org/10.32782/3041-1394.2024-1.8Keywords:
CCH, children, overweight, cytokines, immunoglobulinsAbstract
Studying the dental status of children with overweight and taking into account the factors of local resistance of the oral cavity makes it possible to timely improve and apply measures for the prevention and treatment of chronic catarrhal gingivitis (CCG). Therefore, the aim of our study was to analyze the dynamics of immunological changes in the oral fluid of children with overweight during the treatment of CCG. There were observed 80 children aged 12–15 years with overweight to evaluate immunological changes during the treatment of chronic catarrhal gingivitis (CCG). The study of cytokine content (IL-4, IL-1β, IL-6, TNF-α) was carried out in the oral fluid of 40 children aged 12 years (20 – with overweight, 20 – with obesity) and 40 children 15 years (20 – with overweight, 20 – with obesity). In a comparative plan, 30 practically healthy children (aged 12–15 years) with normal body weight (comparison group) and chronic catarrhal gingivitis were examined. Treatment of CCG in children with overweight was carried out in accordance with the proposed complex of preventive and treatment measured. In the comparison group (children with overweight) and in the control group (children with normal body weight), the treatment of CCG was carried out in accordance with the regional protocols for the provision of dental care. As a result of the application of the proposed complex of preventive and treatment measured, especially of local action of the gel and rinse, on the 12–14th day of the treatment, was found a significant decrease in the proinflammatory cytokines IL-1β, TNF-α in the main group of children compared to the children of the comparison group and control group. An increase in the content of anti-inflammatory IL-4 in the main group of children with overweight compared to the group of children with normal body weight and the comparison group was also observed. Studies indicate a significant difference in the indicators of the content of immunoglobulins in the oral fluid of children with overweight of patients with catarrhal gingivitis, comparing to the children from the comparison group and the control group.
References
Костура В.Л., Безвушко Е.В. Поширеність та структура захворювань тканин пародонта у дітей із надмірною масою тіла. Клінічна стоматологія. 2017. № 2. С. 42–47.
Годованець О.І., Кіцак Т.С. Поширеність ураження тканин пародонту у дітей у разі супутнього дифузного нетоксичного зобу. Вісник стоматології. 2022. № 118 (1). С. 72–75.
Клітинська О.В., Мельник В.С., Ступницька О.М. Аналіз стану тканин пародонта у школярів міста Ужгорода. Український медичний альманах. 2012. Том 15 (3). С. 89–90.
Шевчук М.М. Поширеність і структура хвороб тканин пародонта хворих стаціонару Львівської обласної клінічної лікарні залежно від віку. Український стоматологічний альманах. 2018. № 4. С. 16–21.
Остапко О.І. Стан тканин пародонту у дітей та підлітків, які проживають у різних регіонах України. Новини стоматології. 2015. № 1 (82). С. 78–83.
Common periodontal diseases of children and adolescents / H. Al-Ghutaimel, H.H. Riba, S. Al-Kahtani, S. Al-Duhaimi. International journal of dentistry. 2014.
Diagnosis and management of periodontal disease in children and adolescents: A brief review / V. Kini, R.U. Patil, T. Pathak, A. Prakash, B. Gupta. J Dent Allied Sci. 2016. 5. P. 78–83.
Association between overweight/obesity and periodontal disease in children and adolescents: a systematic review and meta-analysis / L. Martens, S. De Smet, M.Y. Yusof, S. Rajasekharan. Eur Arch Paediatr Dent. 2017. Vol. 18 (2). P. 69–82.
Crocombe Is overweight/obesity a risk factor for periodontitis in young adults and adolescents?: a systematic review / S. Khan, G. Barrington, S. Bettiol, T. Barnett. Obes Rev. 2018. Vol. 19 (6). P. 852–883.
The relationship between children’s body mass index and periodontal status / F. Vaziri, Z. Bahrololoomi, Z. Savabieh, K. Sezavar. J Indian Soc Periodontol. 2022. Vol. 26. №1. P. 64–68.
Evaluation of the relationship between obesity, dental caries and periodontal disease in adolescents / G. Vallogini, V. Nobili, R. Rongo, S. De Rosa, F. Magliarditi, V. D’Antò, A. Galeotti. Eur J Paediatr Dent. 2017. Vol. 1 (4). P. 268–272.
Dental caries and childhood obesity: analysis of food intakes, lifestyle / M. Costacurta, L. DiRenzo, L. Sicuro, i S. Gratter, A. De Lorenzo, R. Docimo. Eur J Paediatr Dent. 2014. Vol. 15 (4). P. 343–348.
Obesity and dental caries in paediatric patients. A cross-sectional study / M. Costacurta, L. Di Renzo, A. Bianchi, F. Fabiocchi, A. De Lorenzo, R. Docimo. Eur J Paediatr Dent. 2011. Vol. 12 (2). P. 112–116.
Dental caries is negatively correlated with body mass index among 7– 9 years old children in Guangzhou, China / J.J. Liang, Z.Q. Zhang, Y.J. Chen, J.C. Mai, J. Ma, W.H. Yang, J. Jing. BMC Public Health. 2016. Vol. 26. P. 16–638.
Body mass index and dental caries in young people: a systematic review / M. Paisi, E. Kay, C. Bennett, I. Kaimi, R. Witton, R. Nelder, D. Lapthorne. BMC Pediatr. 2019. Vol. 19 (1). P. 122.
Association between dental caries and obesity among Libyan schoolchildren during the armed conflict in Benghazi / E. Aoun, L. Ballo, S. Elhabony, A. Arheiam. BMC Oral Health. 2023. Vol. 23 (1). P. 44.
Гель для лікування і профілактики хронічного катарального гінгівіту у дітей з надмірною масою тіла: Пат. 127646 Україна: МПК А61К 31/00, А61К 31/375, А61К 31/593, А61К 6/00, А61К 9/107, А61Р 31/00.; № u 201803537; заявл. 02.04.2018; опубл. 10.08.2018. – Бюл. № 15.
Ополіскувач для лікування і профілактики хронічного катарального гінгівіту у дітей з надмірною масою тіла: Пат. 128817 Україна: МПК А61К 31/00, А61К 31/593, А61К 31/375, А61Q 11/00, А61Р 31/00.; № u 201803492; заявл. 02.04.2018; опубл. 10.10.2018. – Бюл. № 19.
