ІСТОРИЧНІ АСПЕКТИ, ВИДОВА ДИФЕРЕНЦІАЦІЯ ТА МОЖЛИВОСТІ ЗАСТОСУВАННЯ ЛЕЙКОЦИТАРНИХ ФІБРИНОВИХ ЗГУСТКІВ, ЗБАГАЧЕНИХ ТРОМБОЦИТАМИ (L-PRF) (ОГЛЯД ЛІТЕРАТУРИ)
DOI:
https://doi.org/10.32782/3041-1394.2024-3.10Keywords:
fibrin clots, fibrin enriched with leukocytes, platelet concentrates, centrifugation, cytokines, maxillofacial areaAbstract
Introduction. In 2001, J. Choukroun et al. proposed a new type of fibrin clot - leukocyte- and platelet-rich fibrin (L-PRF). Fibrin enriched with leukocytes and platelets is used during surgical interventions in surgical dentistry and maxillofacial surgery. The aim of the study. To conduct a retrospective analysis of domestic and foreign sources of scientific literature, in which the history of the invention, classification, protocols of obtaining and variants of application of the technique of leukocyte fibrin clots enriched with platelets in clinical conditions are considered. Research materials and methods. In the presented retrospective analysis of professional medical publications, 26 fundamental foreign literary sources were studied with a depth of search from 1970 to 2023. Results. Common features of products obtained from the recipient’s own blood are: the use of tubes with anticoagulants and immediate centrifugation of the blood after its collection. Main advantages: simplicity of cooking technology; economic benefit; biocompatibility; ability to prolonged release of growth factors; the availability of the methodology protocol in free access. There are well-known foreign studies on the use of fibrin enriched with leukocytes and platelets in orthodontic treatment to optimize the retraction of retained canines of the upper jaw; closure of Schneider’s membrane perforations; treatment of severe forms of periodontitis; filling the holes of the lower third molars; in the case of immediate installation of dental implants after tooth extraction and in the treatment of peri-implantitis; with bisphosphonate osteonecrosis of the jaws; treatment of non-unions of the alveolar process of the upper jaw in children. Conclusion. Long-term experience of scientists and clinicians from different parts of the world proves the expediency, effectiveness and multivector use of L-PRF in the treatment of pathological processes of the maxillofacial region.
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