FEATURES OF HORMONAL CHANGES IN WOMEN WITH GENERALIZED PERIODONTITIS IN THE CONTEXT OF POLYCYSTIC OVARY SYNDROME
DOI:
https://doi.org/10.32782/3041-1394.2025-1.4Keywords:
polycystic ovary syndrome, generalized periodontitis, estradiol, dehydroepiandrosterone sulfate, hormonal imbalanceAbstract
Introduction. Periodontal diseases are among the most common oral cavity pathologies, significantly affecting patients’ quality of life and overall health. Generalized periodontitis in women with polycystic ovary syndrome (PCOS) increases the risk of this disease due to hormonal changes, insulin resistance, and metabolic disorders. The purpose of the study is to examine hormonal changes and their relationship with the development of generalized periodontitis in women with PCOS. Materials and Methods. The study was conducted from 2019 to 2024 at clinical bases of dental institutions and private reproductive centers in Kyiv. The sample consisted of 60 women with PCOS and generalized periodontitis (Group 1) and 20 women with PCOS without periodontitis (Group 2). Patients underwent clinical, laboratory, and instrumental examinations. Hormonal levels were assessed using electrochemiluminescence detection. Results. In Group 1, violations of hydration were significantly more frequent by 25.0% (p=0.049), and a history of smoking was found 26.7% more often compared to Group 2. In women from Group 1, there was a decrease in estradiol levels and an increase in dehydroepiandrosterone sulfate (DHEA-S), which correlates with the presence of generalized periodontitis. The increase in DHEA-S levels did not affect the severity of periodontitis. Women with periodontitis also showed a decrease in free thyroxine (fT4) levels. Conclusions. Women with PCOS and generalized periodontitis experience significant hormonal imbalances, including decreased estradiol levels and elevated DHEA-S. These hormonal changes contribute to the development and progression of periodontitis, and thus, the treatment of such patients should be comprehensive, including correction of hormonal imbalance and lifestyle.
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